Influences of atorvastatin on pulse wave velocity and ankle-brachial index (ABI) in patients with hypercholesterolemia
YANG Bei
HE Yu-ju
XIE Xi
Abstract：Objective To investigate the short-term influences of atorvastatin on brachial-ankle pulse wave velocity (baPWV) and ankle-brachial index (ABI) in patients with hypercholesterolemia (TC≥5.7 mmol/L and/or LDL-C≥3.6 mmol/L). Methods The patients (n=78) were chosen from the Fourth Affiliated Hospital of Kunming Medical University from May 2011 to Nov. 2011, and then divided randomly into two groups. Control group (n=39) was given diet control only and treatment group (n=39) was given atorvastatin (20 mg/d). The changes of baPWV and ABI were observed and compared between two group before and 6 months after treatment. Results The level of blood fat decreased in two groups after treatment, which was more significant in treatment group (P<0.05). In control group, baPWV and ABI had no changes after treatment [baPWV:(1539±171.9) m/s vs. (1527±232.2) m/s;ABI:(1.2±0.2) vs. (1.2±0.3)], and in treatment group, baPWV decreased [(1442±102.1) m/s vs. (1580±205.2) m/s, P<0.05] and ABI increased [(1.3±0.3) vs. (1.2±0.3), P<0.05], which were improved compared with control group after treatment. Conclusion Atorvastatin can improve baPWV and ABI and relieve peripheral vascular sclerosis in the patients with hypercholesterolemia.
Keywords：Pulse wave velocityBrachial-ankle indexAtorvastatin
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 60-61 )