Correlation between C1562T genetic polymorphism of MMP-9 and susceptivity of senile coronary heart disease
LU Hui
HU Dong-nan
PENG Liang-zhen
WANG Rong
Abstract：Objective To investigate the correlation between C1562T genetic polymorphism of matrix metalloproteinase-9 (MMP-9) and susceptivity of senile coronary heart disease (CHD). Methods The patients (aged≥60, n=168) were chosen as CHD group from the Beijing Aerospace General Hospital from Mar. 2009 to Dec. 2012, and 208 persons with normal physical examinations were chosen as control group. The samples of peripheral blood were collected for extracting DNA. The genotypes of C1562T of MMP-9 were detected by using polymerase chain reaction-restricted fragment length polymorphisms (PCR-RFLP), and difference in frequency distribution of C1562T genetic polymorphism was compared between two groups. Results The differences in genotypes of C1562T genetic polymorphism and allele frequency distribution had statistical significance between two groups (P<0.05). In CHD group, the frequency of allele 1562T was significantly higher than that in control group (20.8%vs. 13.0%, P=0.004). The risk of suffering from CHD in the patients carried allele T was 3.97 times higher than that in those carried allele C (OR=3.97). The distributions of genotypes and allele had no statistical difference (P>0.05) among different clinical types of CHD (stable angina, unstable angina and myocardial infarction). Conclusion C1562T genetic polymorphism of MMP-9 is correlated to senile CHD, and allele T may be a susceptive heredity gene.
Keywords：Coronary heart diseaseMatrix metalloproteinase-9Gene polymorphismHeredity
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 51-53 )