Correlation between genetic polymorphism of apolipoprotein E and late-onset Alzheimer's disease in Chinese population:a Meta-analysis
REN Chang-ju
WENG Hong
CHENG Zhao-hui
ZHANG Chao
AI Zhi-bing
Abstract：Objective To review systematically the correlation between genetic polymorphism of apolipoprotein E (ApoE) and late-onset Alzheimer’s disease (LOAD) in Chinese population. Methods The databases of PubMed, EMbase, CBM, CNKI, WanFang Database and VIP Database were retrieved with computer for collecting the case-controlled studies about the correlation between genetic polymorphism of ApoE and LOAD in Chinese population from database establishing time to Aug. 12, 2013. The data was selected and extracted by two researches, reviewed according to NOS tool and given a Meta-analysis by using Stata 12.0 software. Results There were totally 9 case-controlled studies included involving 732 LOAD patients and 1183 health control people. Meta-analysis showed that the LOAD risk increased by 16.02 times in population with genotypeε4/4 compared those with genotypeε3/3 (OR=16.02, 95%CI:7.08~36.27, P<0.001), by 3.19 times in those with genotypeε3/4 compared with those with genotypeε3/3 (OR=3.19, 95%CI:2.09~4.87, P<0.001), by 3.61 times in those with genotypeε2/4 compared with those with genotypeε3/3 (OR=3.61, 95%CI:1.92~6.79, P<0.001), by 3.71 times in those with alleleε4 compared with those with alleleε3 (OR=3.71, 95%CI:2.49~5.52, P<0.001), and had no statistical difference in those with genotypeε2/3, genotypeε2/2 and alleleε2. Conclusion The current evidence indicates that alleleε4 of ApoE is correlated to LOAD, genotypeε4/4 is a high risk factor and alleleε2 is not correlated to LOAD.
Keywords：Apolipoprotein EGenetic polymorphismLate-onset Alzheimer’s diseaseMeta-analysis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 20-24 )