Relationship between plasma gamma-glutamyl transferase and coronary heart disease
ZHANG Ling
Abstract：Objective To discuss the relationship between plasma γ-glutamyl transferase (GGT) and coronary heart disease (CHD).Methods The patients (n=220) with chest pain were chosen from Mar. 2011 to Jul. 2012, and then divided into CHD group (n=140) and control group (n=80) according to the outcomes of coronary angiography (CAG). CHD group was further divided, according to clinical symptoms and conditions, into stable angina pectoris (SAP) group (n=58), unstable angina pectoris (UAP) group (n=45) and acute myocardial infarction (AMI) group (n=37). The risk factors of CHD including height, weight, blood pressure and smoking history were recorded. The changes of GGT, blood fat and plasma glucose were detected by using enzyme-linked immunosorbent assay (ELISA), and the correlation between GGT level and CHD or its risk factors was reviewed by applying binary Logistic regression analysis.Results In CHD group, GGT level was significantly higher than that in control group [(15.14±7.36) U/L,P<0.01], and as the exacerbating of disease condition, GGT also increased [SAP group: (38.43 ±6.10)U/L, UAP group: (54.68±4.12) U/L and AMI group: (61.32±9.61) U/L,P<0.05]. Logistic regression analysis showed that GGT was an independent risk factor of CHD (OR=4.333, 95%CI: 2.596-7.234).Conclusion GGT is correlated to the degree of CHD and it is an independent risk factor.
Keywords：Glutamyl transferaseCoronary heart diseaseRisk factor
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 633-634 )