Influence of glycosylated hemoglobin on prognosis in nondiabetic patients with acute myocardial infarction
ZHU Ding-jun
CHEN Zhi-qiang
LI Zhen-long
JIN Dao-qun
LIU Zi-yan
XIA Hong-li
WU Yong-bo
ZHANG Kai
Abstract：Objective To review the influence of glycosylated hemoglobin (HbA1c) on the prognosis in nondiabetic patients with acute myocardial infarction (AMI).Methods The AMI patients (n=420) without diabetes were chosen from Jan. 2005 to Dec. 2010. The blood samples were collected immediately after hospitalization for detecting the level of plasma glucose (Glu) by using chromatoptometry and detecting the level of HbA1c by using HPLC. All patients were divided, according to HbA1c level at being hospitalizing, into 3.5%≤HbAlc<5.0% group (group 1, n=122), 5.0%≤HbAlc<5.4% group (group 2, n=87), 5.5%≤HbAlc<6.0% group (group 3, n=109) and 6.0%≤HbAlc<6.4% group (group 4, n=102). The main study endpoint was 1-year all-cause mortality, and second study endpoints were 30-day mortality and CK-MB peak value.Results The total 1-year all-cause mortality was 13.57% in all patients, and 8.2% in group 1, 11.5% in group 2, 13.8% in grouop 3 and 21.6% in group 4. The comparison in 30-day mortality and CK-MB peak value showed there was no statistical difference among all groups (P>0.05). Cox regression model showed that HbAlc was an independent predictive factor of 1-year mortality (OR=1.2, P<0.05).Conclusion The level of HbAlc at being hospitalizing is a predictive index for 1-year mortality in the nondiabetic patients with AMI, and 1-year mortality will increase when the level of HbAlc increases.
Keywords：Acute myocardial infarctionGlycosylated hemoglobinNon-diabetesPrognosis
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 624-626 )