Coronary lesion and clinical prognosis in patients with acute coronary syndrome
SUN Jing
ZENG Qiang
DONG Sheng-yong
SUN Xiao-nan
Abstract：Objective To discuss the correlation between the degree of coronary lesion and clinical prognosis in the patients with acute coronary syndrome (ACS), and analyze the influence factors.Methods The patients (n=729) were chosen from the Chinese PLA General Hospital from Apr. 2007 to Apr. 2008, and then they were divided, according to the outcomes of coronary angiography (CAG), into mild lesion group (coronary stenosis<50%without coronary occlusion,n=51) and severe lesion group (coronary stenosis≥50% with or without coronary occlusion,n=678). The endpoint of follow-up was major adverse cardiovascular events (MACE, including cardiaogenic death, angina pectoris, myocardial infarction and cardiogenic shock). The longest follow-up period was 5 years.Results The median follow-up time was 4.3 years in all patients. The success rate of follow-up was 95.34% (695/729), and there were 49 cases in mild lesion group and 646 in severe lesion group. The incidence of MACE was higher in severe lesion group than that in mild lesion group (32.67%vs. 18.37%,P=0.038). During the follow-up period, there were 18 cases (2.79%) died in severe lesion group and no case died in mild lesion group, and there was statistical difference in survival rate between two groups (P=0.0016). The analysis of Cox multiple regression showed that diabetes and age were risk predictive factors for MACE (diabetes:OR=1.5, 95%CI: 1.13-2.08, P=0.006; age:OR=1.0, 95%CI: 1.00-1.03,P=0.037).Conclusion The incidence of MACE will be higher when coronary stenosis is severer, and diabetes is a predictor of MACE.
Keywords：Acute coronary syndromeMajor adverse cardiovascular eventsFollow-up
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 618-621 )