Opportunity and prognosis of thrombolytic treatment of ST-segment elevation myocardial infarction
LIN Yu-biao
LIN Kang-hua
NING Guan-lin
Abstract：Objective To observe the relationship between opportunity and prognosis of thrombolytic treatment of ST-segment elevation myocardial infarction (STEMI).Methods The patients diagnosed as STEMI (n=229) were chosen from People’s Hospital of Wuchuan City of Guangdong Province from Jul. 2008 to Jun. 2012. All patients were given thrombolytic treatment, and the treatment time was divided into 4 groups according to the periods from disease onset time to thrombolytic time. The period less than 3 h was taken as group 1 (n=67), (3-6) h as group 2 (n=96), (6-12) h as group 3 (n=45) and (12-24) h as group 4 (n=21). The recanalization rate (including chest pain relieving, ST-segment falling back and peak of myocardial enzyme CK-MB advancing) and all-cause mortality within 30 d were observed in all groups.Results As the prolong of the periods from disease onset time to thrombolytic time, recanalization rate decreased continuously [group 1: 82.09% (55/67), group 2: 73.96% (71/96), group 3: 42.22% (19/45) and group 4: 35.00% (7/20)], and all-cause mortality within 30 d increased continuously [group 1: 5.97% (4/67), group 2: 9.38% (9/96), group 3: 11.11% (5/45) and group 4: 15.00% (3/20)]. There was statistical difference among all groups (P<0.05).Conclusion If the time of thrombolytic treatment is earlier, the prognosis will be better in the patients with STEMI. The patients with disease onset time over 12 h still can be given thrombolytic treatment and the prognosis can be improved.
Keywords：ST-segment elevation myocardial infarctionOpportunityThrombolytic treatmentCurative effectPrognosis
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 608-610 )