Thrombelastogram and light transmittance aggregation test for detecting high platelet reactivity after DES implantation
LI Wei
SONG Xian-tao
XU Feng
LV Shu-zheng
Abstract：Objective To observe the difference in the results of clopidogrel-related high platelet reactivity (HTPR) detected by thrombelastogram (TEG) or by light transmittance aggregation test (LTA) in the patients after drug eluting stent (DES) implantation and the influences of positive results of TEG or LTA on prognosis.Methods The patients (n=264) were chosen from Beijing Anzhen Hospital from Jan. 2011 to Oct. 2012. The level of MA-ADP was detected by using TEG and level of LTA-ADP was detected by using LTA. The patients were followed up for 6 months. The major adverse cardiovascular events (MACE, including sudden cardiac death, reinfarction, ischemia stroke, non-planed revascularization and rehospitalization because of coronary ischemia) were recorded. The diagnostic values of TEG and LTA to HTPR were reviewed by applying ROC area under the curve (AUC). The difference in MACE was compared in the patients with positive results of TEG or LTA during follow-up period. Results The diagnostic values of TEG and LTA were different in the diagnosis of HTPR (AUCMA-ADP=0.771vs. AUCLTA-ADP=0.603,Z=2.246,P<0.05). The diagnostic critical value of TEG was 49.1 mm, and when taking which as diagnostic standard the incidence of MACE was higher in the patients with positive results of TEG (19.5%vs. 3.7%,P<0.05). The diagnostic critical value of LTA was 44.5%, and when taking which as diagnostic standard the incidence of MACE was similar in the patients with positive results of LTA and in those with negative results. Conclusion TEG is more accurate and significant than LTA in HTPR detection and prognosis prediction.
Keywords：Drug eluting stent implantationDetection of platelet functionThrombelastogramLight transmittance turbidimetry
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 604-607 )