Correlation between coronary stenosis degree and endothelial dysfunction in patients with coronary heart disease complicating diabetes mellitus
LI Li-qiang
ZHANG Hong-ju
WU Hui-min
ZHANG Rui-hong
LIU Tian
Abstract：Objective To discuss the correlation between coronary stenosis degree and endothelial dysfunction in the patients with coronary heart disease (CHD) complicating type 2 diabetes mellitus (DM).Methods The patients (n=86) diagnosed as CHD by coronary angiography (CAG) were chosen and were divided into DM group (CHD complicating DM,n=46) and NDM group (without DM, n=40). The degree of coronary stenosis was reviewed by using Gensini integral method. The level of plasma NO was detected by using nitrate reductase method. The levels of vWF:Ag and GMP-140 were detected by using ELISA. The activities of t-PA and PAI-1 and injury of endothelial function were determined by using chromogenic substrate assay. Gensini integrals and indexes related to endothelial dysfunction were analyzed by using linear correlation analysis.Results Gensini integrals were significantly higher in DM group than those in NDM group (38.25±12.13vs. 28.73±10.74,P<0.05), and levels of NO and t-PA were significantly lower in DM group than those in NDM group (52.35±17.62 μmol/L, 0.55± 0.21 IU/L; 98.37±21.20 μmol/L, 0.87±0.26 IU/L;P<0.01). The levels of ET, PAI-1, vWF:Ag and GMP-140 were significantly higher in DM group than those in NDM group [77.72±19.34 μmol/L, 0.77±0.26 IU/L, (376.56 ±87.67)%, 29.85±9.12 g/L; 57.68±15.58 μmol/L, 0.51±0.18 IU/L, (239.81±65.73)%, 18.96±8.07 g/L;P<0.01]. The levels of NO and t-PA were negatively correlated to Gensini integrals (r=-0.803,r=-0.628; all P<0.01), while levels of ET, PAI-1, vWF:Ag and GMP-140 were positively correlated to Gensini integrals (r=0.713, r=0.526,r=0.705,r=0.512; allP<0.01).Conclusion Gensini integrals are closely correlated to the degree of endothelial dysfunction, and severe endothelial dysfunction may be one of causes of exacerbated coronary stenosis in the patients with CHD complicating DM.
Keywords：Coronary heart diseaseDiabetesCoronary arteryEndothelial function
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 596-598,601 )