A Meta-analysis on treatment of acute myocardial infarction with Shenmai Injection combining routine therapeutic plan
MA Zhi-yuan
SUN Yu
JIN Yan-ling
JIANG Lin
WANG Wen-jin
Abstract：Objective To review the curative effect and safety of Shenmai Injection combining routine therapeutic plan in treatment of ST-segment elevation myocardial infarction (STEMI).Methods The databases of Cochrane Library, PubMed, Embase, CBM, CNKI, and CSJD were retrieved with computers from establishing time of these databases to Jan. 2013, and at the same time other retrieving methods were applied for collecting randomized controlled trials (RCT) about Shenmai Injection combining routine therapeutic plan in treatment of STEMI. The quality of all RCT was reviewed and data was extracted by two researchers independently. A Meta-analysis was conducted by using RevMan 5.2 software.Results There were totally 16 RCT included involving 1886 cases. The results of Meta-analysis showed as follows: compared with routine therapeutic plan, Shenmai Injection combining routine therapeutic plan reduced mortality (OR=0.46, 95%CI: 0.33-0.63,P<0.00001) and incidences of shock (OR=0.56, 95%CI: 0.35~0.89,P=0.01) and heart failure (OR=0.51, 95%CI: 0.37~0.71,P<0.0001), and there was statistical difference in the decrease of incidence of arrhythmia secondary to STEMI (OR=0.37, 95%CI:0.22~0.63,P=0.0003).Conclusion Shenmai Injection combining routine therapeutic plan can reduced mortality and incidences of shock, heart failure and arrhythmia secondary to STEMI in the treatment of STEMI.
Keywords：Shenmai InjectionMyocardial infarctionMeta-analysis
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 568-572 )