Influence of coenzyme A on serum lipid level in patients with moderate hyperlipidemia

LIN Yu-biao; NING Guan-lin; LIN Kang-hua

doi:10.3969/j.1674-4055.2013.05.22

Abstract：Objective To review the lipid-lowering effect and safety of coenzyme A (CoA) on serum lipid level in the patients with moderate hyperlipidemia. Methods The patients (n=168) were chosen from the Outpatient Department of Internal Medicine of People’s Hospital of Wuchuan City from Sept. 2010 to Dec. 2012 and randomly divided into three groups. Group A (n=54) was given placebo, group B (n=46) was given CoA (200 U/d) and group C (n=68) was given CoA (400 U/d). The changes of blood fat, functions of liver and kidney and blood glucose indexes were detected, and myopathy and gastrointestinal symptoms were recorded respectively before and 4 weeks and 8 weeks after treatment. Results After treatment, TG level decreased in three groups especially in group C [(3.76±0.67) mmol/L vs. (3.22±0.62) mmol/L vs. (2.40±0.54) mmol/L] followed by group B [(3.24±0.95) mmol/L vs. (2.73±0.67) mmol/L vs. (2.54±0.76) mmol/L]. TG level decreased in group A on the 4th week but increased on the 8th week [(3.57±0.78) mmol/L vs. (3.38±0.57) mmol/L vs. (3.54±0.65) mmol/L]. The levels of TC, LDL-C and HDL-C (P>0.05), and blood glucose indexes, functions of liver and kidney, myopathy and gastrointestinal symptoms had no statistical difference (all P>0.05) in three group before and after treatment. Conclusion CoA can effectively reduce TC level in the patients with moderate hyperlipidemia and has no obvious side effects.