Influences of early intensive treatment of atorvastatin on results of emergency PCI in patients with STEMI
YANG Yong
LIU Hui-liang
YANG Sheng-li
LIU Ying
SHEN Zhi-qi
Abstract：Objective To investigate the influences of pre-operation intensive treatment of atorvastatin (80 mg) on post-operation ST-segment resolution index (STRI), serum inflammatory factors and endothelial function in the patients with ST-segment elevation myocardial infarction (STEMI). Methods The STEMI patients (n=95, onset<12 h) who planed accepting emergency PCI were chosen from the General Hospital of Chinese People’ s Armed Police Forces from Mar. 2010 to Dec. 2010, and randomly divide into group A (n=34, 80 mg atorvastatin before PCI and 40 mg/d after PCI), group B (n=34, no atorvastatin before PCI and 40 mg/d after PCI) and group C (n=30, no atorvastatin before PCI and 20 mg/d after PCI). The changes of STRI within 90 min after PCI, and high sensitivity C-reactive protein (hs-CRP) and NO synthase (NOS) after PCI for 24 h, 3 d and 7 d were observed. Results Within 90 min after PCI, the percentage and extent of ST-segment resolution were higher in group A compared with those in group B and group C (P<0.05). After PCI for 24 h, the level of hs-CRP decreased in group A, which had no statistical difference compared with group B and group C. After PCI for 3 d and 7 d, the level of hs-CRP decreased further in group A, which had statistical difference compared with group B and group C (P<0.05). After PCI for 24 h and 3 d, the level of NOS was higher in group A than that in group B and group C, which had no statistical difference (P>0.05). After PCI for 7 d, the level of NOS increased continuously in group A, which had statistical difference compared with group B and group C (P<0.05). Conclusion The one-time administration of high-dose atorvastatin (80 mg) before emergency PCI is benefit to alleviate the myocardial perfusion and inflammatory reactions, and improve vascular endothelial function in STEMI patients.
Keywords：AtorvastatinST-segment elevation myocardial infarctionHigh sensitivity C-reactive proteinNO synthaseST-segment resolution index
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 489-491 )