Influences of candesartan on plasma urotensin II and adiponectin in patients with hypertension complicating type 2 diabetes

LIU Mei-xun; LEI Feng-qin

doi:10.3969/j.1674-4055.2013.05.09

Abstract：Objective To compare the antihypertensive effects of candesartan and felodipine and their influences on the levels of plasma urotensinⅡ(UⅡ) and adiponectin (ADI) in the patients with hypertension complicating type 2 diabetes. Methods The patients (n=84) were chosen and randomly divided into candesartan group (4 mg, qd) and felodipine group (5 mg, qd) and treated for 16 weeks. The antihypertensive efficacies of these two drugs were compared. The levels of plasma UⅡ, ADI and angiotensinⅡ(AngⅡ) were detected by applying enzyme-linked immunosorbent assay (ELISA) and radioimmunoassay before and after treatment. The influences of these two drugs on the above-mentioned vasoactive substances were observed. Results The level of blood pressure decreased in tow groups after treatment but there was no statistical difference between two groups. The levels of U II, ADI and AngⅡhad no statistical difference between two groups before treatment (P>0.05), and after treatment for 16 weeks, in candesartan group, compared with felodipine group, U II level decreased significantly [(6.17±1.45) pmol/L vs. (8.92±1.21) pmol/L, P<0.01], ADI level increased significantly [(6.13±1.45) mg/L vs. (4.12±1.46) mg/L, P<0.01], and AngⅡlevel had no statistical difference between two groups [(149.72±22.89) mg/L vs. (143.27 ±23.88) mg/L, P>0.05]. Conclusion Candesartan is superior to felodipine in reducing the levels of UⅡand ADI in the patients with hypertension complicating type 2 diabetes.