Comparison in curative effects of facilitated PCI and primary PCI on acute myocardial infarction：a Meta-analysis
ZHU Zhang-guo
LIU Ting-zhu
LI Ling
MAO Hua
WEN Mei
Abstract：Objective To review systematically the difference in curative effects and safety between facilitated PCI and primary PCI in the treatment of acute myocardial infarction (AMI). Methods The databases of Cochrane Library, PubMed, CBM and WangFang Database were retrieved for collecting randomized controlled trials (RCT) or clinical controlled trials (CCT) about the curative effects of facilitated PCI and primary PCI taken AMI as research objects. The outcomes were compared and given Meta-analysis by using RevMan4.2 software. Results There were totally 17 RCT included involving 1498 cases, and the results of Meta-analysis showed as follows:①Compared with primary PCI group, the patency rate of infarction related artery (IRA) before PCI was significantly higher in facilitated PCI group (OR=3.51, 95%CI:2.60-4.73), especially the TIMI 3 flow of IRA (OR=4.31, 95%CI:2.88-6.45). ②There were no statistical differences in mortality, incidence of cardiac events and no-reflow during hospitalization between two groups (OR=1.14, 95%CI:0.50-2.61;OR=1.05, 95%CI:0.60-1.84;OR=0.41, 95%CI:0.13-1.30). ③The amelioration of left ventricular ejection fraction (LVEF) was much better in facilitated PCI group than that in primary PCI group (WMD=4.89, 95%CI:1.49-7.44). Conclusion Facilitated PCI is safe and has better curative effect in the treatment of AMI compared with primary PCI indicated by current data. Because the quality of total included RCT is lower, more RCT with higher quality are required for further identifying the results.
Keywords：Acute myocardial infarctionAngioplastyTransluminalPercutaneous coronary interventionThrombolysisMeta-analysis
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 457-462 )