A Meta-analysis on relationship between patent foramen ovale and cryptogenic stroke in middle aged and elderly people
MA Bing
CHEN Xin
LIU Yi-ting
ZHANG Jian-ming
SHI Jing-pu
Abstract：Objective To study the relationship between patent foramen ovale (PFO) and cryptogenic stroke in middle aged and elderly people, and provide the evidence for etiological research of cryptogenic stroke. Methods The databases of PubMed, Embase, Web of Science, CNKI, VIP and WanFang were retrieved for selecting the case-controlled trials about PFO and cryptogenic stroke in middle aged and elderly people. The relationship between PFO and cryptogenic stroke were analyzed and reviewed by using Meta-analysis and Stata11.0 software. Results There were totally 10 trials obtained. The results of Meta-analysis showed that PFO was the risk factor of cryptogenic stroke (OR=2.09, 95%CI:1.61-2.71). The effect size gotten from pooled OR after adjusting separately was 2.65 (95%CI: 1.81-3.88) which had statistical significance. The results of subgroup analysis showed that the effect size decreased to 1.37 and reached a threshold effect (95%CI:1.00-1.88) in group aged below limiting value<55 after grouping according to the age lower limit (55 years old) of the patients. The effect sizes had no changes in all subgroups (P<0.05) after grouping according to publishing time, control group, stroke diagnostic method and PFO diagnostic method. Conclusion PFO may be a risk factor of cryptogenic stroke in middle aged and elderly people.
Keywords：Patent foramen ovaleMiddle aged and elderly peopleCryptogenic strokeMeta-analysis
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 453-456 )