Effect of naringenin on myocardial ischemia-reperfusion injury in rats
XU Ai-bin
WANG Fei
LI Jun-xia
WANG Shi-hong
LI Meng
Abstract：Objective To observe the effect of naringenin (NAR) on myocardial ischemia-reperfusion injury (IRI) in rats. Methods Male SD rats (weighted 220 g to 250 g, n=32) were randomly divided into control group, IRI group, NAR group 1 (50 mg/kg) and NAR group 2 (100 mg/kg, each n=8). NAR group 1 and NAR group 2 were intraperitoneally injected NAR two hours before IRI. The model of IRI was established as follows:ligating the left anterior descending coronary artery for 30 minutes and then giving reperfusion for 180 minutes. After three hours, the levels of serum interleukin 1β(IL-1β), tumor necrosis factor-α(TNF-α), lactic dehydrogenase (LDH), creatine kinase (CK), superoxide dismutase (SOD) and malondialdehyde (MDA), and infarction area after reperfusion for 24 hours were detected in all groups. Results Compared with control group, the infarction area was significantly reduced and the levels of serum IL-1β, TNF-α, LDH, CK and MDA decreased in NAR groups (P<0.05), and SOD level (P<0.05) increased showing concentration dependent. Conclusion NAR has a significant effect on myocardial IRI, and the mechanism may be related to inhibiting inflammatory reaction after IRI and relieving oxidative stress injury.
Keywords：NaringeninMyocardial protectionIschemia-reperfusion injuryInflammationOxygen free radicalRats
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 416-418 )