Levels of troponin I and uric acid in patients with coronary artery lesions

WANG Yan-wei; GAO Shu-jun; ZHAO Chang-zeng; QI Shu-ying

doi:10.3969/j.1674-4055.2013.04.026

Abstract：Objective To investigate the changes of troponin I (TnI) and uric acid (UA) in the patients with coronary artery lesions in varying degrees. Methods The patients with coronary heart disease (CHD) diagnosed by coronary angiography (CAG) were chosen as CHD group (n=80) and the cases without CHD as non-CHD group (n=26). The CHD group was divided again into single-vessel group (n=29), double-vessel group (n=29) and multi-vessel group (n=22) according to the number of diseased coronary vessels. The stenosis degree of coronary arteries was calculated by using accumulative integration method. The levels of TnI and UA were detected and the correlation between the levels of TnI and UA and stenosis degree of coronary arteries was analyzed statistically. Results The levels of TnI and UA were, respectively, (0.014±0.01) μg/L and (295.682±45.43) μmol/L in control group. The level of TnI was, respectively, (5.453±12.29)μg/L, (16.022±28.56)μg/L and (20.552± 30.25)μg/L, and UA, respectively, (357.821±74.91)μmol/L, (389.907±82.19)μmol/L and (401.122±83.81)μmol/L in single-vessel group, double-vessel group and multi-vessel group. The levels of TnI and UA were significantly higher in CHD group than those in control group (P<0.05), and meanwhile, those were higher in multi-vessel group than those in single-vessel group (P<0.05). The difference in levels of TnI and UA had no statistical significance between double-vessel group and multi-vessel group (P>0.05). The levels of TnI and UA were positively correlated to the stenosis degree of coronary arteries (r=0.673, r=0.440, P<0.01). Conclusion The levels of TnI and UA increase significantly in CHD patients, and the severe of coronary artery lesions is correlated to the levels of TnI and UA.