Changes and clinical significance of serum osteoprotegerin and its receptor in patients with idiopathic pulmonary arterial hypertension
ZHANG Han
LIU Feng
LI Yan-ming
YAO Xin-liang
ZHONG Xiao-ming
WAN Qi-lin
Abstract：Objective To study the relationship between pulmonary arterial pressure and the levels of serum osteoprotegerin (OPG) and its receptor (RANKL) and clinical significance in the patients with idiopathic pulmonary arterial hypertension (IPAH). Methods IPAH patients were chosen as IPAH group (n=28) and other health persons with the same sex and age were chosen as control group (n=28). The levels of serum OPG, RANKL and NT-proBNP were detected by using enzyme-linked immunosorbent assay (ELISA), and the level of pulmonary arterial pressure was detected by applying right heart catheterization. The correlation between pulmonary arterial pressure and OPG and RANKL levels was analyzed. Results The levels of OPG, RANKL and NT-proBNP were higher in IPAH group than those in control group [OPG:(190.91±43.39) pg/mL vs. (122.59±41.20) pg/mL;RANKL:(194.05 ±50.31) pg/mL vs. (117.73±39.89) pg/mL;NT-proBNP:(1894.78±591.97) pg/mL vs. (224.18±60.11) pg/mL, P<0.05]. Linear correlation analysis showed that OPG and RANKL levels were positively correlated to pulmonary arterial pressure (r=0.525, P<0.05 and r=0.419, P<0.05). Conclusion OPG and RANKL levels may take part in the incidence of IPAH and are correlated to pulmonary arterial pressure.
Keywords：Idiopathic pulmonary arterial hypertensionOsteoprotegerinPulmonary arterial pressure
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 396-398 )