Short-term curative effect of anti-hypertensive drugs on isolated diastolic hypertension
HAN Yun-feng
WANG Ying-qi
FAN Xiao-han
Abstract：Objective To compare the short-term curative effect of different anti-hypertensive drugs in the untreated patients with isolated diastolic hypertension. Methods The patients (n=104, aged from 40 to 75) with isolated diastolic hypertension for the first time were chosen, and then divided into four groups:hydrochlorothiazide group (n=37,12.5 mg/d-25 mg/d), atenolol group (n=19, 12.5 mg/d-25 mg/d), nifedipine group (n=27, 20 mg/d-40 mg/d) and captopril group (n=21, 25 mg/d-50 mg/d). The curative effect was compared after four weeks. Results The diastolic blood pressure was significantly decreased in all patients after treatment for four weeks. After adjusting age, sex, body mass index, waistline and waist-hip ratio, and relative blood pressure, blood fat, blood sugar, smoking and drinking before treatment, there was no statistical difference among four groups. But hydrochlorothiazide and nifedipine had more significant effect of reducing diastolic blood pressure compared with atenolol (P=0.040) and captopril (P=0.016). Conclusion Atenolol and captopril have less effects on diastolic blood pressure, so they are more suitable for the patients with isolated diastolic hypertension.
Keywords：Isolated diastolic hypertensionAnti-hypertensive drugsCurative effect
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 352-354 )