Sodium zirconium cyclosilicate:research progress on a novel potassium binder
YANG Shi-jie
ZHUANG Jie
LIU Qian
NIU Jian-zhao
Abstract：This paper reviews the research progress of sodium zirconium cyclosilicate,a novel potassium binder.Sodium zirconium cyclosilicate is a non-absorbed,insoluble,non-polymer inorganic crystalline powder with a uniform microporous structure,and functions as a highly selective inorganic cation exchanger.When taken orally,it captures potassium ions in the human intestinal tract,which are then excreted in the feces.By reducing potassium ion absorption,it lowers the potassium ion level in the blood,thereby treating hyperkalemia.Sodium zirconium cyclosilicate has a high affinity for potassium ions that is unaffected by other cations.Compared with existing treatments for hyperkalemia,it offers improved selectivity and speed in capturing excess potassium ions,providing a safe and effective option for the long-term management of hyperkalemia.This article describes in detail the chemical structure,mechanism of action,pharmacokinetic characteristics,clinical research progress and pharmaceutical research progress of sodium zirconium cyclosilicate.Studies have shown that sodium zirconium cyclosilicate demonstrates favorable efficacy and safety in the treatment of hyperkalemia,offering a new option for clinical practice.
Keywords：sodium zirconium cyclosilicatepotassium ion binderhyperkalemiacrystal structurephar-macokinetics
Publication Date：2026-07-30
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：8( 1502-1509 )