Quality and efficacy evaluation of curcumin-coaxial drug-loaded composite fibrous membranes
JI Yang
LIU Ming-xia
WANG Yu-ning
WEI Guang-chao
PAN Hao
Abstract：Objective:To design a coaxial drug-loaded composite fiber membrane with a core-shell structure.The coaxial drug-loaded fiber membrane was fabricated using electrospinning and electrospraying techniques,achieving satisfactory quality with demonstrated efficacy in promoting wound healing and antibacterial activity.Methods:Physicochemical characterization,quality control,and in vitro and in vivo efficacy evaluation were conducted on the fabricated composite fiber membrane.Results:The coaxial nanofibers exhibited a distinct core-shell structure and excellent antibacterial efficacy.H&E staining and VEGF immunohistochemistry confirmed that the coaxial drug-loaded composite fiber membrane promoted collagen synthesis,accelerated neovascularization,and facilitated wound healing.Conclusion:The prepared coaxial drug-loaded composite fiber membrane meets all the testing requirements and can effectively promote wound healing and inhibit bacteria,providing a new approach for the development of novel wound dressings.
Keywords：curcuminelectrospinning technologybacteriostasiscomposite fibrous membranewound dressing
Publication Date：2026-07-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 1426-1431 )