Nanotechnology-assisted traditional Chinese medicine for non-small cell lung cancer:advances and prospects
QIN Yi-xuan
WANG Xuan-yang
YAN Yi-bing
LIU Jin-tao
HAN Ya-zhou
WANG Bei-lei
XUE Jia-qian
ZHOU Qing-wei
Abstract：The incidence and mortality rate of non-small cell lung cancer(NSCLC)rank among the highest among malignant tumors globally.Currently,the management of NSCLC patients poses significant challenges in clinical practice,characterized by high postoperative complication mortality rates and substantial side effects from drug therapy.In recent years,nanomedicine approaches have emerged by providing efficient nano-drug delivery systems that precisely deliver anticancer drugs to cancer cells,overcoming the limitations of traditional chemotherapy to enhance NSCLC treatment efficacy.Furthermore,traditional Chinese medicine(TCM)demonstrates remarkable advantages in the prevention and treatment of NSCLC.Various TCM monomers,active components,and compound formulations enhance immunity,improve quality of life,and reduce NSCLC metastasis risk through multi-component,multi-target,and multi-pathway mechanisms.However,they face challenges such as poor water solubility,low bioavailability,and insufficient targeting specificity.Nano-delivery systems address these issues by enhancing the bioavailability and solubility of active TCM components while enabling precise targeting of cancer cells for efficient and accurate NSCLC treatment.Therefore,this article reviews the research progress in the synergistic treatment of NSCLC using TCM-nano strategies based on nano-delivery systems,while exploring their application prospects,aiming to develop new methods and approaches for NSCLC therapy.
Keywords：nano-delivery systemnon-small cell lung cancertraditional Chinese medicine-nanoresearch progressapplication prospect
Publication Date：2026-06-30
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：10( 1278-1287 )