Research progress in antibody-dependent enhancement of human immunodeficiency virus
JIANG Yu
XU Ting-ting
LI Chen-jie
ZHANG Zhi-peng
ZHANG Heng
ZHOU Lu
QIU Yun-liang
Abstract：Antibody-dependent enhancement(ADE)refers to the phenomenon where certain non-neutralizing antibodies or sub-neutralizing concentrations of antibodies do not eliminate viruses during viral infection but instead promote viral invasion and replication.In human immunodeficiency virus(HIV)infection,it has been found that some antibodies can form immune complexes with the virus and mediate viral entry into target cells through Fc receptors(FcR)or the complement system,thereby exacerbating disease progression.In recent years,with the in-depth study of HIV infection,the ADE phenomenon has received extensive attention in the development and clinical application of HIV vaccines.This article reviewed the mechanism of ADE in HIV infection,the influencing factors of ADE occurrence,and the implications of ADE for drug development,and explored the impact and potential risks of ADE in HIV infection in depth,providing theoretical support for the development of safe and effective HIV vaccines and antibody drugs.
Keywords：antibody-dependent enhancementhuman immunodeficiency virusreceptorvaccine safetyantibody therapy
Publication Date：2026-06-30
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：7( 1263-1269 )