Progress in research and application of organoid technology in drug research and development
ZHONG Hao-dong
NIU Qian-yi
LIN Tian
ZHANG Rui-qiu
ZHAO Man-man
ZHOU Xiao-bing
Abstract：Drug development is a complex and time-consuming process,and traditional drug research models have obvious limitations,and there is an urgent need to establish a new model system.Organoids are three-dimensional tissue analogues derived from stem cells that have attracted attention for their excellent physiological relevance.Organoid technology has shown great application potential in the fields of disease modeling,drug screening,toxicity testing,and personalized medicine,and can also be combined with organ-on-a-chip technologies to provide a new platform for the construction of complex physiological correlation models and the study of multi-organ interactions.This article reviews the development history of organoid technology and the progress in its research and application in drug development,discusses the challenges and development directions,to provide references for the key process of drug development and help promote the application and development of organoid technology in drug research and development.
Keywords：organoidspersonalized medicineorgan-on-a-chip
Publication Date：2026-06-30
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 1251-1256 )