Radionuclide selection,conjugation strategies,and CMC considerations for quality control differences in radionuclide drug conjugates
DAI Yi-fei
XIE Yu-jia
JIANG Tao
TU Zhi-jun
WANG Ming-hong
REN Feng
Abstract：Radionuclide drug conjugates(RDCs)have shown great potential in the field of nuclear medicine due to their precise targeting and radioactive killing capability.This article comprehensively reviews the selection criteria of radionuclides in RDCs and various conjugation strategies between radionuclides and targeting ligands,and provides an in-depth discussion on the differences in quality control for different radionuclides,aiming to provide a reference for the pharmaceutical research and evaluation of RDCs,and help realize their integrated precision diagnosis and treatment in more diseases.
Keywords：radionuclide drug conjugatesconjugation strategyquality controlpharmaceutical research
Publication Date：2026-06-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：7( 1138-1144 )