Study on biological properties,antibacterial and analgesic activities of ibuprofen-loaded photocrosslinked hydrogel wound dressing
ZHOU Yu-chen
ZHANG Liang-liang
LIU Yang
Abstract：Objective:To develop multifunctional hydrogels with excellent antibacterial properties and biocompatibility for the treatment of bacterial infection wounds,which can rapidly heal wounds and relieve pain.Methods:A three-dimensional porous composite hydrogel was prepared by using methacrylated gelatin and polyacrylamide as raw materials and loading copper sulfide particles and ibuprofen through photo-crosslinking.The hydrogel has good biocompatibility and antibacterial properties.The morphology and structure of the hydrogel were characterized by scanning electron microscopy(SEM),Fourier transform infrared spectroscopy(FT-IR),X-ray diffractometer(XRD),etc.The swelling and degradation properties,mechanical properties and rheological properties of the drug-loaded PAAM/GelMA composite hydrogel were analyzed.Meanwhile,in vitro biological experiments were conducted to verify its excellent biocompatibility and explore its antibacterial properties.Results:The PG-CuS@Ib hydrogel displayed a high swelling performance(100％±5％),which can effectively absorb exudate.The antibacterial tests against Escherichia coli and Staphylococcus aureus showed that the inhibition rates were both over 99％.In the biocompatibility test,the survival rate of MC3T1-E1 cells was high,the cell morphology was spread out,and there was no obvious hemolysis(＜5％).Conclusion:The PG-CuS@Ib multifunctional composite hydrogel can meet the key requirements for wound healing.In general,the PG-CuS@Ib hydrogel has promising prospects as a wound dressing.
Keywords：copper sulfide nanoparticlesibuprofenantibacterial activityrelieve painhydrogel
Publication Date：2026-05-30
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：10( 1072-1081 )