Quantitative analysis of five benzenesulfonate ester compounds by qHNMR
CHEN Zhong-lan
YANG Hui-ying
ZHANG Ya-jun
WU Xian-fu
Abstract：Objective:To establish quantitative proton nuclear magnetic resonance(qHNMR)method to determine the contents of methyl benzenesulfonate,propyl benzenesulfonate,isopropyl benzenesulfonate,methyl p-toluenesulfonate,and isopropyl p-toluenesulfonate.Methods:Proton nuclear magnetic resonance spectroscopy(qHNMR)spectra were collected by BRUKEANANCE NEO 600 MHz NMR spectrometer.The parameters were set up as follows:30° pulse sequences,the relaxation delay time was 10 s,the number for scanning was 16,and the experiment temperature was controlled at 25 ℃,dimethyl terephthalate were used as internal standard,respectively.The quantitative study of benzenesulfonate ester compounds was carried out in CDCl3-d as solvents.Results:Using dimethyl terephthalate as internal standard,the contents of five benzenesulfonate ester compounds determined by qHNMR method were basically consistent with the results obtained by mass balance method.Conclusion:The qHNMR method established in this study is simple,rapid,and accurate,and can be used for the determination of benzenesulfonate ester compounds,providing strong evidence data for the accurate assignment of the reference material.
Keywords：qHNMRbenzenesulfonate ester compoundsgenotoxicitydimethyl terephthalate
Publication Date：2026-05-30
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 1057-1062 )