Study on identification of key quality control indicators of Crataegi Fructus slices based on"appearance characteristics-chemical composition"correlation model
LÜ Fang
SUN Meng-yu
LIU Wei
MA Jia-mu
ZHAI Chang-qi
QI Xiao-dan
ZHANG Feng
LI Ming-xia
YING Le-tian
SHE Gai-mei
Abstract：Objective:To construct the correlation model of"appearance characteristics-chemical components"of Crataegi Fructus by integrating appearance characteristics(diameter,thickness and total mass)and internal quality indicators(water content,extract,total ash and HPLC characteristic spectrum)to identify the key quality control indicators of Crataegi Fructus.Methods:After measuring the indicators,principal component analysis(PCA),orthogonal partial least squares discriminant analysis(OPLS-DA),factor analysis(FA)and IQR variability analysis were used for data mining,and key indicators were determined by cross-validation of multiple methods.Results:PCA and OPLS-DA identified seven indicators,including water content,chlorogenic acid,cryptochlorogenic acid,et al.FA extracted cryptochlorogenic acid,hyperoside,and isoquercitrin.IQR analysis yielded 11 variability indicators.Overall,cryptochlorogenic acid and hyperoside were identified as core indicators across all three analytical methods.Conclusion:The correlation model of"appearance characteristics-chemical composition"of Crataegi Fructus was established,and the key quality control indexes were determined as cryptochlorogenic acid and hyperoside,which provided a new research method for the standardization of quality of Chinese herbal slices.
Keywords：Crataegi Fructuskey indicatorsquality evaluation
Publication Date：2026-05-30
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：11( 1046-1056 )