Patent analysis of small molecule CGRP/CGRP-R antagonists
KANG Peng-cheng
WU Ya-nan
Abstract：Calcitonin gene-related peptide(CGRP)is a neuropeptide with potent vasodilatory effect,closely associated with migraine attacks.CGRP and its receptor(CGRP-R)are currently the most promising targets for the treatment and prevention of migraine.The migraine treatment drugs for CGRP mainly include CGRP-R an-tagonists and CGRP monoclonal antibodies.By blocking the binding of CGRP to its receptor,CGRP-R antagonists can have a similar effect on migraine as triptans,with a lower incidence of adverse reactions.They are more effec-tive and safe new drugs for treating migraine.The author used the incoPat database to search and count the patent applications of small molecule CGRP/CGRP-R antagonists,analyzed the overall trend of patent applications,geo-graphical distribution,applications of important applicants,the distribution of technical fields of patent applica-tions,and the core patents of key varieties,and tried to reflect the patent application status of small molecule CGRP/CGRP-R antagonists,reveal their development trend,and give relevant suggestions.It provides a reference for domestic pharmaceutical companies and research institutions.
Keywords：CGRPCGRP-Rantagonistsmigrainepatent analysis
Publication Date：2026-04-30
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：8( 819-826 )