Design strategies of targeted nano-drug delivery systems and advances in tumor precision therapy
ZHANG Yun
ZHENG Yu
XU Ning
ZHANG Ya-li
YANG Nan
MA Bin-yu
Abstract：Targeted nano-drug delivery systems(NDDS)have provided a new strategy for the precise ther-apy of tumor.NDDS,as novel modes of drug delivery,are capable of penetrating various biological barriers to de-liver therapeutic agents precisely to tumor sites.By leveraging their unique size effect,controlled release,stimula-tion response,ease of modification and functionalization,these systems enhance drug stability and solubility,im-prove bioavailability,and reduce systemic toxicity and side effects.Consequently,they enable targeted drug deliv-ery and theranostics,offering promising solutions to overcome the therapeutic limitations of conventional chemother-apeutic agents.This paper summarizes the advantages of NDDS,the classification,principles and targeted design strategies of nano-carriers,focuses on the types of commonly used targeting ligands and their mechanisms of action,analyzes the current developments and challenges in scalable production,in vivo transport,biocompatibility and clinical translation,and looks forward to the prospects of future applications,with the aim of providing references for the further development and clinical applications.
Keywords：nano-drug delivery systemtargetingtumorprecision therapynano-carrier
Publication Date：2026-04-30
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：9( 795-803 )