Advances in surface-functionalized brain-targeted nano-drug delivery systems
ZHANG Yu
LU Sheng-nan
ZHANG Jun-li
ZHANG Yao-yao
CHENG Ling
LI Jing
LI Ying
SU Feng
HE Guang-wei
Abstract：Central nervous system(CNS)diseases have become a major global public health challenge.With the extension of human lifespan and the intensification of population aging,the incidence of these diseases has shown a significant upward trend,yet their clinical treatment still faces critical technological bottlenecks.The pres-ence of the blood-brain barrier(BBB)hinders the delivery of over 98%of small-molecule drugs and nearly all macromolecular drugs into the brain,rendering conventional drug administration methods unable to achieve effective therapeutic concentrations.In recent years,brain-targeted nano-drug delivery systems based on nanotechnology have demonstrated breakthrough potential:nanocarriers can improve the efficiency of drug crossing the BBB through size effects;surface functional modifications enable precise drug delivery to the brain.This article describes the composition and function of the BBB,the types of nanocarriers,and brain-targeting strategies via functional group modifications,aiming to provide theoretical foundations and technical references for developing safe and efficient brain-targeted nano-drug delivery systems.
Keywords：nano-drug delivery systembrain-targetingfunctional group ligandblood-brain barriernanocarrierscentral nervous system
Publication Date：2026-04-30
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：10( 785-794 )