Successful correction of perioperative hypoalbuminemia with recombinant human albumin injection(Oryza Sativa)in a patient with allergy to human serum albumin:a case report
Diligeer·TAYIER
QIN Xian
LIAO Ru-fang
YANG Zhi-yong
Abstract：This article reports the case of a 70-year-old female patient scheduled for surgical intervention due to a space-occupying lesion at the distal common bile duct.The patient presented with severe allergic reactions to plasma-derived human serum albumin(pHSA),precluding its use for correcting hypoalbuminemia.Following informed consent,recombinant human albumin injection(Oryza Sativa)(OsrHSA)was administered as an alternative.The patient received a total of 70 g OsrHSA preoperatively in divided infusions,and her serum albumin level increased from 29.1 g·L-1 to 37.3 g·L-1 without adverse events.She subsequently underwent laparoscopic pancre-aticoduodenectomy without complications.OsrHSA was also administered multiple times postoperatively,and no allergic reactions were observed.This case represented the successful application of OsrHSA as a safe alternative to pHSA in perioperative management for complex surgery.To the authors'knowledge,no similar reports have been published to date.This provides a new therapeutic avenue for patients with contraindications to human serum albumin,suggesting that plant-derived recombinant human albumin represents a safe and effective alternative.
Keywords：rice-derived recombinant human albuminhuman serum albuminanaphylaxisperioperative applicationhypoalbuminemia
Publication Date：2026-04-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 780-784 )