Efficacy and safety of baloxavir and oseltamivir for children with influenza:a Meta-analysis
ZENG Yuan-yuan
LI Wen-jing
Abstract：Objective:To investigate the safety and efficacy of baloxavir marboxil versus oseltamivir in children treated for influenza.Methods:Databases including PubMed,The Cochrane Library,Embase,CNKI,WanFang Data and VIP were searched to collect cohort studies on the use of baloxavir marboxil and oseltamivir in children with influenza.This Meta-analysis was conducted using RevMan 5.4 software.Results:A total of 6 cohort studies involving 2 395 children were included.The result of the Meta-analysis showed that baloxavir marboxil group had a significantly shorter duration of fever(95%CI:[-29.03～-6.69],P=0.002)and the duration of symptoms(95%CI:[-20.55～-3.74],P=0.005)compared to the oseltamivir group.Additionally,the incidence of total adverse events(95%CI:[0.2～0.5],P<0.000 01)and the incidence of gastrointestinal adverse reactions(95%CI:[0.17～0.52],P<0.000 1)were significantly lower in the baloxavir marboxil group.Conclusion:Current evidence suggests that baloxavir marboxil may offer superior efficacy and a better safety profile compared to oseltamivir for treating influenza in children.However,further support from long-term large-scale clinical data on children is still needed.
Keywords：baloxavir marboxiloseltamivirchildreninfluenzaMeta-analysis
Publication Date：2026-03-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 546-551 )