Signal mining and analysis of drug-induced hypotension in older patients based on FAERS database
NI Wen-qi
ZHU Feng
ZHOU Shuang
ZHANG Ya-tong
ZHAO Zi-nan
YANG Qi-liang
LIU Xiao-ying
CUI Yi-min
Abstract：Objective:To mine and analyze risk signals of adverse drug reactions associated with hypotension in older patients within the US FDA adverse event reporting system(FAERS)database,providing evidence to guide safe medication use in elderly adults.Methods:Reports of hypotension in elderly patients(aged≥60 years)from the FAERS database between Q12004 and Q42024 were collected.Disproportionality analysis methods,including the reporting odds ratio(ROR)and proportional reporting ratio(PRR),were used to detect safety signals for drugs implicated in hypotension among this population.Results:After data cleaning,82 048 elderly patients with hypotension were identified,encompassing 82 844 reports.A total of 272 drugs exhibited positive safety signals,34 of which lacked documented hypotension risk in their labeling.The majority of signal-positive drugs fell into cardiovascular agents and nervous system agents.Conclusion:Many drugs are associated with hypo-tension risk in elderly patients.The risk level of drug-induced hypotension should be considered to optimize drug therapy in clinical practice.
Keywords：elderly patientsdrug-induced hypotensionpharmacovigilancesignal miningUS FDA adverse event reporting system
Publication Date：2026-02-28
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：10( 422-431 )