Literature analysis of erythrodermic type skin lesions caused by dupilumab
LI Mei-yun
WANG Yang-yang
WEN Jing
LIU Li-hua
HE Xin
CHEN Shen-jue
Abstract：Objective:To review the case reports of erythrodermic skin lesions caused by dupilumab,analyze the occurrence rules and characteristics,and provide references for clinical safe and rational drug use.Methods:The cases of erythrodermic skin lesions caused by dupilumab were analyzed by searching CNKI,Wanfang Data,Vipnet,PubMed,Web of Science,and other databases.Results:There were 6 cases of erythrodermic skin lesions caused by dupilumab,involving a total of 8 patients,including 7 males and 1 female,aged from 26 to 82 years old,which occurred within 3 to 150 days after medication,mostly within 2 weeks after medication.The main involved areas were the face,trunk,and limbs.The recovery time was mostly within 7 to 20 days.After improvement,5 patients re-used the drug,among whom 2 patients did not have recurrence,and 3 patients had recurrence,but the severity and recovery time were reduced and shortened compared with the previous occurrence.Conclusion:Clinicians should pay close attention to the erythrodermic skin lesions of dupilumab and strengthen monitoring during medication to facilitate timely diagnosis and treatment,ensuring medication safety.
Keywords：dupilumaberythrodermic skin lesionsliterature analysis
Publication Date：2026-02-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 332-336 )