Advances in novel ocular drug delivery systems
BI Xiao-shuang
ZHAO Jian
JI Mu-se
WU Tao
YIN Tian
ZHANG Yu
Abstract：Ophthalmic drug delivery has long faced many challenges due to the complex physiological barriers and rapid clearance mechanisms of the eye,which leads to low bioavailability,frequent adverse reactions,and poor patient compliance with conventional ophthalmic formulations.In order to overcome these limitations,researchers have developed a variety of new ophthalmic drug delivery systems in recent years,aiming at prolonging drug retention time on the ocular surface,enhancing intraocular penetration,and increasing the drug concentration in the target tissue.This review systematically summarizes the research progress of new ophthalmic drug delivery systems,including both marketed products and those under clinical investigation.It elaborates in detail on their formulation design,mechanism of action,and therapeutic efficacy.According to the different routes of administration,the review highlights representative strategies such as ocular surface delivery systems(e.g.,nano-drug delivery systems,non-aqueous solvent delivery systems,ophthalmic gels,drug-eluting contact lenses,and lacrimal canaliculus implants),periocular delivery systems(e.g.,subconjunctival and suprachoroidal administration),intraocular delivery systems(e.g.,implants in the anterior chamber and vitreous body),as well as nasal mucosa delivery system and drug-mechanical combined delivery systems.Finally,the future development of the new ophthalmic drug delivery system is prospected.
Keywords：new ophthalmic drug delivery systemresearch progresseye barrierbioavailability
Publication Date：2026-02-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：10( 275-284 )