Adverse events caused by antibody-drug conjugate in a patient with advanced pancreatic cancer and literature analysis
XIE Hong-mei
QIAN Huo-lian
YANG Meng-meng
WANG Qiang
Abstract：Objective:To investigate the adverse events associated with antibody-drug conjugates(ADCs)during clinical trials,providing references for further clinical research on the drugs.Methods:A case of advanced pancreatic cancer patient treated with ADC who developed peripheral neuropathy,ocular toxicity,elevated transaminase levels,and hyperglycemia was reported.The Naranjo scale was used to evaluate the association between ADC and these adverse events.The possible mechanisms of adverse events caused by ADCs were analyzed based on literature review.Results:After symptomatic treatment,the patient's transaminase and blood glucose levels returned to normal.Although the symptoms of peripheral neuropathy improved,they still slightly limited his daily life.The ocular adverse events recovered after symptomatic treatment and delayed medication.The correlation between the patient's peripheral neuropathy,elevated transaminase,hyperglycemia,and ADC was judged as"possible",while the correlation between ocular toxicity and ADC was"definite".Conclusion:The adverse reactions of ADCs are complex.Clinical trial staff should pay attention to risk identification,evaluation,and coping strategies to better protect the safety of subjects.
Keywords：antibody-drug conjugateclinical trialsadverse reactionpancreatic cancer
Publication Date：2026-01-30
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 220-224 )