The impact of drug transporter polymorphisms on anti-cancer drug disposition
TIAN Guan-fang
YANG Zi-wei
CHEN Yue-wen
WANG Xiao-liang
WANG Ze
Abstract：Drug transporters are critical membrane proteins that facilitate the transmembrane transport of drugs,endogenous molecules,and toxins via ATP hydrolysis or ion/concentration gradients.These transporters significantly impact drug absorption,distribution,metabolism,and excretion,and are essential to drug safety and efficacy.They are classified two major families:ATP-binding cassette(ABC)transporters and solute carrier(SLC)transporters.Single nucleotide polymorphisms in transporter genes have a significant influence on drug metabolism and individual variability.In recent years,advances in genomics have led to increasing reports linking transporter gene polymorphisms to differences in drug disposition and clinical efficacy.This paper reviews some key polymorphisms in drug transporters that are associated with anti-cancer drug disposition,with the aim of supporting rational clinical drug use and facilitating personalized anti-cancer therapy.
Keywords：transporterssingle nucleotide polymorphismATP-binding cassette transporter familysolute carrier transporter familyanti-cancer drug
Publication Date：2026-01-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：5( 41-45 )