Analysis of the current status and trends in recombinant protein vaccine research and development
XU Li
LI Huan
LIU Min
LI Xiao-jing
HE Wu
Abstract：Recombinant protein vaccines have become a pivotal tool in the infectious disease prevention and control system,owing to their distinct safety advantages,favorable stability,and potential for large-scale production.This article systematically reviewed the entire technological chain of recombinant protein vaccines,focusing on key advances in rational antigen design,the application of expression systems,and adjuvant development.Through analysis of vaccine cases targeting respiratory syncytial virus,SARS-CoV-2,and herpes zoster,the study elucidates how antigen structural design,adjuvant innovation,and integration of technological platforms synergistically drive the more scientific and efficient development of recombinant protein vaccines.Furthermore,the article explores cutting-edge research directions,including AI-assisted antigen screening and design,broad-spectrum vaccines,mucosal immunization vaccines,and regulatory science pathways based on platform technologies.Looking ahead,recombinant protein vaccine technology,through interdisciplinary integration,will continue to play a central role in enhancing vaccine efficacy and improving response speed to emerging and re-emerging infectious diseases.
Keywords：recombinant proteinvaccineexpressionantigen designadjuvantplatform
Publication Date：2025-12-30
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：8( 2577-2584 )