Analysis patent applications in therapeutic anti-tumor antibodies
BI Qing
LI Jie
Abstract：Antitumor antibodies enhance the body's resistance to tumor cells by modulating the immune system or targeting molecules that are overexpressed on the surface of tumor cells,secreted into the extracellular space,and involved in tumor cell growth.These antibodies can directly inhibit or kill tumors,as well as deliver cytotoxic payloads to tumor cells in cancer treatment.With the development of biotechnology and pharmaceutical industry,antibody drugs have emerged as focal point in cancer treatment due to their unique advantages.They have become first-line treatment options for some types of tumors.Based on the patent information related to anti-tumor antibodies combined with the information of antibody drugs globally approved or under approval by World Health Organization-listed Authorities,this study conducts statistical analysis to study the overall situation of global and Chinese patent applications,technical distribution,valuable applicants and their related products.The essential patented technologies and research trending related to the core technical directions in the field of anti-tumor antibodies are discussed,including modifications of antibody constant region(Fc region),constructions of antibody drug conjugate and preparations of bispecific antibody.
Keywords：anti-tumor antibodiesbispecific antibodyantibody drug conjugatepatent analysis
Publication Date：2025-12-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：9( 2472-2480 )