Advances in anti-Chikungunya fever drugs
LI Jin-yu
LI Song
ZHONG Wu
Abstract：Chikungunya fever(CHIKF)is a mosquito-borne infectious disease caused by the Chikungunya virus(CHIKV).It is primarily characterized by clinical manifestations such as fever,arthralgia and rash.Although the fatality rate is relatively low,it can lead to chronic arthritis and persistent joint dysfunction,significantly impacting patients' quality of life.Currently,there are no specific antiviral drugs available,and clinical management mainly focuses on symptomatic and supportive care.In recent years,advances in virological and molecular biology research have gradually elucidated the life cycle and pathogenic mechanisms of CHIKV,providing new targets for drug development.This article systematically reviews the virological characteristics,epidemiological features,and clinical manifestations of CHIKV,with a focus on summarizing recent progress in the development of small-molecule inhibitors targeting viral entry,replication,and assembly.Additionally,the mechanisms of action and potential applications of these inhibitors are discussed.
Keywords：Chikungunya feverChikungunya virusantiviral drugsmall-molecule inhibitorvector-borne disease
Publication Date：2025-11-30
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：21( 2378-2398 )