Application of organoids in endometrial physiological models,disease mechanisms and therapeutic research
TIAN Shu-ting
LIU Li
DENG Yi-fang
Abstract：The endometrium is an important part of the female reproductive system,characterized by a variety of physiological functions and complex structures.At present,due to the lack of research models to characterize the genesis and developmental characteristics of the endometrium,the research on the mechanism of endometrial diseases and the development of therapeutic drugs is limited.Organoids are self-assembled three-dimensional cellular structures that retain many physiologically relevant and functional features of their native tissue.The genetic,histological,and biological characteristics of endometrial organoids are consistent with those of the original tissues and organs.These organoids not only respond to exogenous hormones,thereby reproducing the physiological cycle of endometrium in vitro,but also simulate the complex process of blastocyst implantation.This article reviews the application and prospect of endometrial organoids in physiological fertility,disease research,and clinical translation.
Keywords：organoidsendometrial diseasesdrug screeningregenerative medicine
Publication Date：2025-10-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 2062-2067 )