Physiopathologic role of the proteasome and progress in the development of targeted drugs
ZUO Rui
ZHOU Qiu-hua
JI Xiao-jun
SU Jin-cai
XU Dan
WU Jian
Abstract：Proteasomes are widely distributed in cells and play important a regulatory role in most cell biological pathways to maintain protein homeostasis.They can be further divided into constitutive and immune types.Abnormalities in its function have been found to be closely related to the development and progression of tumors,infectious diseases,neurodegenerative diseases,and autoimmune diseases.Currently marketed drugs are mainly pan-proteasome inhibitors,and some immune-based proteasome inhibitors are under development.This article provides a review of the structure and function of the proteasome,its physiopathologic roles,and the current status of drug discovery and development against proteasomes,which will bring new thoughts and insights into the study of the proteasome and the development of targeted drugs.
Keywords：proteasomeconstitutiveimmune typeubiquitin-proteasome systemproteasome and diseasetargeted drug
Publication Date：2025-10-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：8( 2041-2048 )