A retrospective analysis of literature cases of myocarditis associated with immune checkpoint inhibitors in China
WU Yu-pei
WANG Ze-pu
GUO Shao-wei
WANG Miao-miao
YIN Yue-song
ZHANG Li-na
Abstract：Objective:To analyze the characteristics and patterns of myocarditis associated with immune checkpoint inhibitors(ICIs)in China,providing a reference for rational clinical drug dosing.Methods:Authors conducted a comprehensive search of CNKI,Wanfang,VIP,as well as PubMed and Web of Science to collect case reports of myocarditis caused by ICIs in China(up to June 2024).Data were extracted and analyzed accordingly.Results:A total of 143 cases in 132 literatures were includedin this study.The median age of patients was 66 years old,and the primary disease was lung cancer in the majority(28.67%).The onset time of myocarditis was 83.92%within 90 days of the first medication,with the median time of 24 days.The first symptoms of myocarditis were mainly chest tightness,shortness of breath,palpitation(59.44%)and fatigue(37.76%).Manifestations of myocarditis related cardiovascular adverse events were tachyarrhythmia(35.66%),bradyarrhythmia(19.58%),heart failure(12.59%),acute coronary syndrome(4.90%)and cardiogenic shock(4.90%).15(10.49%)patients died of myocarditis.Conclusion:Myocarditis caused by ICIs in China mainly occurs in the early stage of immunotherapy,with the first symptoms mainly chest tightness,shortness of breath,palpitations and fatigue.During ICIs dosing,monitoring should be strengthened to identify myocarditis related cardiovascular events in time to ensure the safety of drug dosing.
Keywords：immune-related adverse eventsmyocarditiscardiovascular adverse eventsimmune checkpoint inhibitors
Publication Date：2025-09-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 1891-1896 )