A systematic review of the efficacy and safety of ferrous succinate tablets in the treatment of iron deficiency anemia during pregnancy
CHEN Zhuo
GAO Li
WANG Hui
LIU Lu
YAN Mei-xing
Abstract：Objective:To systematically evaluate the efficacy and safety of ferrous succinate tablets in the treatment of iron deficiency anemia during pregnancy.Methods:Retrieved from PubMed,Embase,Cochrane Library,CNKI,Wanfang,randomized controlled trials(RCTs)about ferrous succinate versus polysaccharide iron complex capsules and ferrous sulfate tablets in the treatment of anemia during pregnancy and different dosage forms of ferrous succinate tablets for the treatment of iron-deficiency anemia in pregnancy were collected from January 2016 to April 2024.Meta-analysis was performed using RevMan 5.3 and Stata 17.0 software.Results:A total of 47 RCTs were retrieved with 6 655 patients.Results of meta-analysis showed that ferrous succinate tablets were significantly better than ferrous sulfate tablets in terms of overall efficacy[OR=4.65,95%CI(3.68,5.88),P<0.000 01]and incidence of adverse reactions(P<0.05).There was no statistical significance in total response rate[OR=1.47,95%CI(0.45,4.79),P=0.52]and specific adverse effect rates(P>0.05)between ferrous succinate tablets and polysaccharide iron complex capsules.The overall effectiveness and total incidence of adverse drug reactions in ferrous succinate sustained-release tablets were significantly better than that of ferrous succinate film-coated tablets.Conclusion:The efficacy and safety of ferrous succinate tablets in treating iron deficiency anemia in pregnancy are both good.
Keywords：ferrous succinateanemia in pregnancyefficacysafetymeta-analysis
Publication Date：2025-09-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：9( 1882-1890 )