Study on the quality of echinocandin antibiotics-Ⅱ
LI Bin
LI Jin
NING Bao-ming
DI Xin
TIAN Ye
Abstract：Echinocandin are semi synthetic antibiotics.In the process from strain fermentation to clinical use,process impurities or degradation impurities are easily introduced into these drugs.The above impurities usually have complex structures and are similar to the structures of active components,so they may compete with drugs for the target of action and affect the safety and effectiveness of drugs.Therefore,it is important to study the sources and structures of impurities for the quality control of drugs.This review summarizes the pharmacopoeia inclusion of echinocandin,the precursor structure and the development process of structural modification,and analyzes the possible sources of impurities,structures and quality control,so as to provide a reference for the quality research and control of echinocandin.
Keywords：echinocandinimpuritiesquality controlstructural modification
Publication Date：2025-08-03
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：12( 1723-1734 )