New lipid-lowering drugs affecting lipid metabolism by regulating autophagy
JI Hui
YUAN Shan-hui
LU Yun-tao
WANG Qian
TANG Hui
Abstract：The drug treatment related to dyslipidemia is currently a hot research topic in the cardiovascular field.Dyslipidemia is closely related to cardiovascular diseases,especially hyperlipidemia.Autophagy refers to a phenomenon that damaged or excess organelles and proteins are decomposed in lysosomes,which plays an important role in maintaining cell homeostasis and coping with external environmental pressure.Autophagy also plays an important role in lipid metabolism.Autophagy can degrade lipid droplets and reduce lipid deposition,thus maintaining the homeostasis of lipid metabolism.Our previous study found that autophagy may regulate hepatocyte autophagy by regulating the expression of key enzymes of lipid metabolism,thus affecting the homeostasis of liver lipid metabolism.Different autophagy regulation pathways play different roles in the process of lipid metabolism in liver,and interact with the lipolysis pathway mediated by traditional lipase.In this paper,the research progress of new lipid-lowering drugs that affect lipid metabolism by regulating autophagy is systematically reviewed.
Keywords：autophagyautophagy regulatingliver lipid metabolismnew lipid-lowering drugs
Publication Date：2025-08-03
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：7( 1716-1722 )