Prediction of quality markers for Gegen Decoction based on chemical composition and network pharmacology
JIANG Kang
YANG Xue-mei
ZHANG Jing-hua
XIA Yu-feng
Abstract：Gegen Decoction,known for its therapeutic properties of inducing sweating to release the exterior and generating fluids to soothe the meridians,is indicated for the treatment of conditions such as common cold with wind-cold syndrome,headaches,dizziness,spinal diseases,and periarthritis of shoulder.In clinically,Gegen Decoction is extensively utilized for the treatment of common cold with wind-cold syndrome.The Chinese Pharmacopoeia(2020 edition)solely employs puerarin as the quality control index component for Gegen Decoction-related preparations,which fails to capture the synergistic effects of multiple components and targets inherent in traditional Chinese medicine formulas,and thus cannot accurately represent the overall quality of the preparation.Based on the comprehensive analysis of the chemical constituents of Gegen Decoction,this study applies network pharmacology research methods in conjunction with the core theory of quality marker(Q-marker)to predict and analyze the Q-markers for Gegen Decoction.The findings reveal that puerarin,formononetin,daidzein,ephedrine,pseudoephedrine,6-gingerol,and isoliquiritigenin are key active components of Gegen Decoction,which can serve as its Q-markers,providing a scientific basis for the control and enhancement of the quality standards of Gegen Decoction.
Keywords：Gegen Decoctioncommon cold with wind-cold syndromenetwork pharmacologychemical constituentsquality marker
Publication Date：2025-08-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：9( 1593-1601 )