Chinese expert consensus on clinical application of levofolinic acid in the sensitization of chemotherapy for gastrointestinal tumors
LIU Bo
ZHANG Hong-yan
Abstract：Chemotherapy is an important method for the treatment for colorectal cancer;however,the therapeutic effect of chemotherapy drugs remains unsatisfactory,accompanied by many adverse reactions and individual differences.Researchers have found that chemotherapy sensitizers are of great significance for colorectal cancer.These agents not only improve the therapeutic effect of chemotherapy drugs,but also reduce their adverse reactions.The combination of fluorouracil(5-FU)and levo-folic acid is an important treatment scheme for digestive tract tumor patients.5-FU is a classic drug that needs to be used with chemosensitization,but the current effect is less than satisfactory.Levofolinic acid is a new sensitizer,a left-handed isomer of folinic acid,serving as the active ingredient(the right-handed isomer cannot be utilized in the body).Levofolinic acid includes both levofolinic acid sodium and levofolinic acid calcium.To better guide and standardize the application of a chemosensitizer(levofolinic acid)in digestive tract tumors,the Professional Committee of the Chinese Anti-Cancer Association for Tumor Whole Assessment has organized experts to integrate the evidence-based medicine and expert clinical practice experience of levofolinic acid,as a chemosensitizer,and jointly formulated this consensus.
Keywords：chemotherapeutic sensitizerslevofolinic acid for injectiongastrointestinal tumorsfluorouracil
Publication Date：2025-07-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 1396-1401 )