The research and application progress of large language models in drug development
GUO Jin-long
XU Xin
LIU Li-li
MAO Yan-yan
Abstract：Large language models(LLMs)have gained increasing attention for their potential to facilitate scientific discoveries across various disciplines,significantly influencing the field of drug development.The types of LLMs related to drug development are diverse,including general-purpose LLMs,protein LLMs,and molecular LLMs.These models hold great promise for applications in target discovery and identification,protein structure and function prediction,drug molecule design and optimization,drug property prediction,drug repurposing and combination therapies,and automated experimentation.Currently,LLMs are in the early stages of rapid development.However,the challenge remains to effectively integrate these models into innovative drug research and development practices in order to fully realize their potential value over time.
Keywords：large language modelscientific large language modelsdrug research and developmentapplication progress
Publication Date：2025-07-15
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：7( 1384-1390 )